PDB entry 3h1v

View 3h1v on RCSB PDB site
Description: Human glucokinase in complex with a synthetic activator
Class: transferase
Keywords: glucokinase, diabetes, allosteric activator, Alternative splicing, ATP-binding, Diabetes mellitus, Disease mutation, Glycolysis, Kinase, Nucleotide-binding, Polymorphism, Transferase
Deposited on 2009-04-14, released 2009-10-06
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-10-06, with a file datestamp of 2009-10-02.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.235
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'X':
    Compound: Glucokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.05: d3h1vx1, d3h1vx2
  • Heterogens: GLC, TK1, NA, HOH

PDB Chain Sequences:

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >3h1vX (X:)
mveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpegsevgdf
lsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyisecisdfl
dkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaikrrgd
femdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegrmcvn
tewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlvdenl
lfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrracesv
straahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrltpsc
eitfieseegsgrgaalvsavackkacmlgq

    Sequence, based on observed residues (ATOM records): (download) 
    >3h1vX (X:)
mveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpegsevgdf
lsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyisecisdfl
dkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaikrrgd
femdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegrmcvn
tewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlvdenl
lfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrracesv
straahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrltpsc
eitfieseegsgrgaalvsavackka