PDB entry 3h0a
View 3h0a on RCSB PDB site
Description: Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist
Class: transcription
Keywords: PPAR, transcription, nuclear receptor fold, transcription regulation, hormone, growth factor receptor, complex, DNA-binding, Host-virus interaction, Isopeptide bond, Metal-binding, Nucleus, Receptor, Zinc-finger, Activator, Diabetes mellitus, Disease mutation, Obesity, Phosphoprotein, Acyltransferase, Proto-oncogene, Transferase
Deposited on
2009-04-08, released
2009-06-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-04-02, with a file datestamp of
2014-03-28.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.251
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Retinoic acid receptor RXR-alpha
Species: Homo sapiens [TaxId:9606]
Gene: RXRA, NR2B1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3h0aa_ - Chain 'B':
Compound: Nuclear receptor coactivator 1, Co-activator Peptide
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Peroxisome proliferator-activated receptor gamma
Species: Homo sapiens [TaxId:9606]
Gene: PPARG, NR1C3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3h0ad_ - Chain 'E':
Compound: Nuclear receptor coactivator 1, Co-activator Peptide
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: 9RA, D30, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3h0aA (A:)
edmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewakrip
hfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifd
rvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckhk
ypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmeml
Sequence, based on observed residues (ATOM records): (download)
>3h0aA (A:)
edmpverileaelavendpvtnicqaadkqlftlvewakriphfselplddqvillragw
nelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmqmdkt
elgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllrlpal
rsiglkclehlfffkligdtpidtflmeml
- Chain 'B':
No sequence available.
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3h0aD (D:)
pesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfk
hitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvhei
iytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdla
ifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqi
vtehvqllqvikktetdmslhpllqeiykdly
Sequence, based on observed residues (ATOM records): (download)
>3h0aD (D:)
pesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikqe
qskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlas
lmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiavii
lsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvql
lqvikktetdmslhpllqeiykdly
- Chain 'E':
No sequence available.