PDB entry 3gyf

View 3gyf on RCSB PDB site
Description: Human DHFR with Z-isomer in Orthorhombic lattice
Class: oxidoreductase
Keywords: human dihydrofolate reductase packing, Z-isomer furopyrimidine, NADP, One-carbon metabolism, Oxidoreductase
Deposited on 2009-04-03, released 2009-11-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.223
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHFR, DHFRP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3gyfa_
  • Heterogens: 51P, NDP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gyfA (A:)
mvgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfs
ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
evyeknd

    Sequence, based on observed residues (ATOM records): (download) 
    >3gyfA (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd