PDB entry 3gwu

View 3gwu on RCSB PDB site
Description: Leucine transporter LeuT in complex with sertraline
Class: transport protein
Keywords: NEUROTRANSMITTER, TRANSMEMBRANE TRANSPORT, INTEGRAL MEMBRANE PROTEIN, ANTIDEPRESSANT, NSS, TRANSPORT PROTEIN, Symport, Transmembrane, Transport
Deposited on 2009-04-01, released 2009-05-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transporter
    Species: Aquifex aeolicus [TaxId:224324]
    Gene: aq_2077, LeuT, snf
    Database cross-references and differences (RAF-indexed):
    • Uniprot O67854 (Start-512)
      • expression tag (513-514)
    Domains in SCOPe 2.07: d3gwua1, d3gwua2
  • Heterogens: LEU, NA, SRE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3gwuA (A:)
    mevkrehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmw
    iewamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfai
    kflvglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinv
    silirgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkd
    pgvwiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisip
    aavaffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaim
    qpmiafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffgltel
    iiffwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeeth
    wtvwitrfyiiglflfltflvflaerrrnhesagt
    

    Sequence, based on observed residues (ATOM records): (download)
    >3gwuA (A:)
    rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
    mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
    glvpeppptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirg
    iskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwia
    avgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaff
    gvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmiaf
    ledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwi
    fgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwit
    rfyiiglflfltflvflaerrrnhesagt