PDB entry 3gvu

View 3gvu on RCSB PDB site
Description: The crystal structure of human ABL2 in complex with GLEEVEC
Class: transferase
Keywords: Tyrosine kinase, ABL, Abelson murine leukemia viral oncogene, ATP-binding, Cell adhesion, Cytoskeleton, Kinase, Lipoprotein, Magnesium, Manganese, Metal-binding, Myristate, Nucleotide-binding, Phosphoprotein, SH2 domain, SH3 domain, Transferase, Tyrosine-protein kinase, Structural Genomics, Structural Genomics Consortium, SGC
Deposited on 2009-03-31, released 2009-04-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ABL2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42684 (24-291)
      • expression tag (14-23)
    Domains in SCOPe 2.08: d3gvua1, d3gvua2
  • Heterogens: STI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gvuA (A:)
mghhhhhhssgvdlgtenlyfqsmdkwemertditmkhklgggqygevyvgvwkkysltv
avktlkedtmeveeflkeaavmkeikhpnlvqllgvctleppfyivteympygnlldylr
ecnreevtavvllymatqissameylekknfihrdlaarnclvgenhvvkvadfglsrlm
tgdtytahagakfpikwtapeslayntfsiksdvwafgvllweiatygmspypgidlsqv
ydllekgyrmeqpegcppkvyelmracwkwspadrpsfaethqafetmfhds

    Sequence, based on observed residues (ATOM records): (download) 
    >3gvuA (A:)
gtenlyfqsmdkwemertditmkhklgggqygevyvgvwkkysltvavktlkedtmevee
flkeaavmkeikhpnlvqllgvctleppfyivteympygnlldylrecnreevtavvlly
matqissameylekknfihrdlaarnclvgenhvvkvadfglsrgdtytakfpikwtape
slayntfsiksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvy
elmracwkwspadrpsfaethqafetmfhds