PDB entry 3gug

View 3gug on RCSB PDB site
Description: Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid
Class: oxidoreductase
Keywords: Aldo-keto reductase, 20 alpha hydroxysteroid dehydrogenase, AKR1C1, OXIDOREDUCTASE, Cytoplasm, NADP, Polymorphism
Deposited on 2009-03-30, released 2010-02-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-02-09, with a file datestamp of 2010-02-05.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.194
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member C1
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C1, DDH, DDH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04828 (Start-322)
      • engineered (307)
    Domains in SCOPe 2.08: d3guga_
  • Heterogens: NAP, C2U, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gugA (A:)
mdskyqcvklndghfmpvlgfgtyapaevpkskaleatklaieagfrhidsahlynneeq
vglairskiadgsvkredifytsklwcnshrpelvrpalerslknlqldyvdlylihfpv
svkpgeevipkdengkilfdtvdlcatweavekckdaglaksigvsnfnrrqlemilnkp
glkykpvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlledpv
lcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidgln
rnvryltvdifagppnypfsdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3gugA (A:)
qcvklndghfmpvlgfgtyapaevpkskaleatklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwcnshrpelvrpalerslknlqldyvdlylihfpvsvkpg
eevipkdengkilfdtvdlcatweavekckdaglaksigvsnfnrrqlemilnkpglkyk
pvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlledpvlcala
kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidglnrnvry
ltvdifagppnypfsdey