PDB entry 3gs7
View 3gs7 on RCSB PDB site
Description: Human transthyretin (TTR) complexed with (E)-3-(2-methoxybenzylideneaminooxy)propanoic acid (inhibitor 13)
Class: hormone
Keywords: transthyretin, inhibitor, crystal structure, amyloid, Amyloidosis, Disease mutation, Gamma-carboxyglutamic acid, Glycoprotein, Hormone, Neuropathy, Polymorphism, Retinol-binding, Secreted, Thyroid hormone, Transport, Vitamin A
Deposited on
2009-03-26, released
2009-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-07-28, with a file datestamp of
2009-07-24.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.227
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3gs7a_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3gs7b_ - Heterogens: 8BD, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3gs7A (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3gs7A (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3gs7B (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3gs7B (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvt