PDB entry 3gs4
View 3gs4 on RCSB PDB site
Description: Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid (inhibitor 15)
Class: hormone
Keywords: transthyretin, inhibitor, crystal structure, amyloid, Amyloidosis, Disease mutation, Gamma-carboxyglutamic acid, Glycoprotein, Hormone, Neuropathy, Polymorphism, Retinol-binding, Secreted, Thyroid hormone, Transport, Vitamin A
Deposited on
2009-03-26, released
2009-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-07-28, with a file datestamp of
2009-07-24.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: 0.228
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3gs4a_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3gs4b_ - Heterogens: 7BD, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3gs4A (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3gs4A (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3gs4B (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3gs4B (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandrrytiaallspysysttavvtn