PDB entry 3grg
View 3grg on RCSB PDB site
Description: Crystal structure of the F87M/L110M mutant of human transthyretin at pH 7.5
Class: transport protein
Keywords: transthyretin, Amyloid, Amyloidosis, Disease mutation, Gamma-carboxyglutamic acid, Glycoprotein, Hormone, Neuropathy, Retinol-binding, Secreted, Thyroid hormone, Transport, Vitamin A, TRANSPORT PROTEIN
Deposited on
2009-03-25, released
2010-04-07
The last revision prior to the SCOPe 2.06 freeze date was dated
2010-10-20, with a file datestamp of
2010-10-15.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.194
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766
- engineered (86)
- engineered (109)
Domains in SCOPe 2.06: d3grga_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766
- engineered (86)
- engineered (109)
Domains in SCOPe 2.06: d3grgb_ - Chain 'C':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766
- engineered (86)
- engineered (109)
Domains in SCOPe 2.06: d3grgc_ - Chain 'D':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766
- engineered (86)
- engineered (109)
Domains in SCOPe 2.06: d3grgd_ - Heterogens: ZN, ACT, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3grgA (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3grgA (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtnp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3grgB (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3grgB (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtn
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3grgC (C:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3grgC (C:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtn
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3grgD (D:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3grgD (D:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtn