PDB entry 3gr4

View 3gr4 on RCSB PDB site
Description: activator-bound structure of human pyruvate kinase m2
Deposited on 2009-03-24, released 2009-04-07
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FBP, TLA, DYY, UNX, ADP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3gr4A (A:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3gr4A (A:)
iqtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnva
rlnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikgsgtaev
elkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgadf
lvtevenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvh
evrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkm
migrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypl
eavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivlt
ksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnf
amnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3gr4B (B:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3gr4B (B:)
iqtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnva
rlnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikeveatlk
itldnaymekcdenilwldyknickvvevgskiyvddglislqvdflvtevenggslgsk
kgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknik
iiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigrcnragkpvic
atqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavrmqhliareae
aaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrp
rapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkg
dvvivltgwrpgsgftntmrvvpvp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3gr4C (C:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3gr4C (C:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikgsgtaeve
lkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgadfl
vtevenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhe
vrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmm
igrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdyple
avrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltk
sgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfa
mnvgkargffkkgdvvivltgwrpftntmrvvpvp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3gr4D (D:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3gr4D (D:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglivelkkgatl
kitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkdflvtevenggs
lgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekg
knikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigrcnragk
pvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavrmqhlia
reaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgrsahqva
ryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargf
fkkgdvvivltgwrpgsgftntmrvvpvp