PDB entry 3gpc

View 3gpc on RCSB PDB site
Description: Crystal structure of human Acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a complex with CoA
Class: ligase
Keywords: middle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, ATP-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, ligase, nucleotide-binding
Deposited on 2009-03-23, released 2009-04-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acyl-coenzyme A synthetase ACSM2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2, ACSM2A, MACS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered mutation (56)
    Domains in SCOPe 2.08: d3gpca_
  • Chain 'B':
    Compound: Acyl-coenzyme A synthetase ACSM2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2, ACSM2A, MACS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered mutation (56)
    Domains in SCOPe 2.08: d3gpcb_
  • Heterogens: MG, COA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gpcA (A:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3gpcA (A:)
ghqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaan
vlsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmskak
aivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqea
saiyftsgglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmepw
algactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvtv
gesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiidd
kgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyfq
fmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfls
hdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3gpcB (B:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3gpcB (B:)
wghqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaa
nvlsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmska
kaivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqe
asaiyftsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmepw
algactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvtv
gesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiidd
kgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyfq
fmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfls
hdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk