PDB entry 3ghv

View 3ghv on RCSB PDB site
Description: Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex
Class: oxidoreductase
Keywords: dihydrofolate reductase, folate enzyme, active site mutants, NADP, One-carbon metabolism, Oxidoreductase
Deposited on 2009-03-04, released 2009-09-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.16
AEROSPACI score: 0.76 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHFR, DHFRP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00374 (0-185)
      • engineered (34)
      • engineered (63)
    Domains in SCOPe 2.07: d3ghva_
  • Heterogens: GHC, NDP, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ghvA (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfkrmtttssvegkqnlvimgkktwfsi
pekfrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd