PDB entry 3ght

View 3ght on RCSB PDB site
Description: Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Third stage of radiation damage.
Class: oxidoreductase
Keywords: OXIDOREDUCTASE, Acetylation, Cataract, Cytoplasm, NADP, Phosphoprotein, Polymorphism
Deposited on 2009-03-04, released 2009-03-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-12-22, with a file datestamp of 2009-12-18.
Experiment type: XRAY
Resolution: 1.1 Å
R-factor: 0.092
AEROSPACI score: 0.99 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: aldose reductase
  Species: Homo sapiens [TaxId:9606]
  Gene: AKR1B1, ALDR1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P15121 (0-315)
    • see remark 999 (4)
  Domains in SCOPe 2.08: d3ghta_
• Heterogens: NDP, LDT, CIT, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ghtA (A:)
  masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
  eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
  effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
  avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
  hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
  llsctshkdypfheef