PDB entry 3ghh

View 3ghh on RCSB PDB site
Description: Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.
Class: hydrolase
Keywords: CD38, CYCLIC ADP RIBOSE, ECTO-ADP-RIBOSYL CYCLASE, 2-GLYCOSIDASE, Glycosidase, Hydrolase
Deposited on 2009-03-03, released 2010-03-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ecto-NAD+ glycohydrolase (CD38 molecule)
    Species: Bos taurus [TaxId:9913]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9TTF5
      • engineered (186)
    Domains in SCOPe 2.08: d3ghha_
  • Chain 'B':
    Compound: Ecto-NAD+ glycohydrolase (CD38 molecule)
    Species: Bos taurus [TaxId:9913]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9TTF5
      • engineered (186)
    Domains in SCOPe 2.08: d3ghhb_
  • Heterogens: SO4, 2NF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ghhA (A:)
ykwhysglnrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdp
ckatkedynslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrw
cgepgssdlniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsm
sifgrvqapnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsr
dqflqrs

    Sequence, based on observed residues (ATOM records): (download) 
    >3ghhA (A:)
nrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdpckatkedy
nslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrwcgepgssd
lniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsmsifgrvqa
pnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsrdqflqr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ghhB (B:)
ykwhysglnrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdp
ckatkedynslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrw
cgepgssdlniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsm
sifgrvqapnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsr
dqflqrs

    Sequence, based on observed residues (ATOM records): (download) 
    >3ghhB (B:)
lnrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdpckatked
ynslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrwcgepgss
dlniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsmsifgrvq
apnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsrdqfl