PDB entry 3ggt

View 3ggt on RCSB PDB site
Description: HIV PR drug highly resistant patient's variant in complex with darunavir
Class: hydrolase
Keywords: darunavir, resistance, mutation score, HIV protease, TMC-114, HYDROLASE
Deposited on 2009-03-02, released 2009-08-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-01-18, with a file datestamp of 2012-01-13.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.192
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus type 1 (BRU ISOLATE) [TaxId:11686]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367 (0-98)
    • engineered (11-12)
    • engineered (14)
    • engineered (19)
    • engineered (31-32)
    • engineered (42)
    • engineered (53-54)
    • engineered (61-62)
    • engineered (70-72)
    • engineered (76)
    • engineered (81)
    • engineered (83)
    • engineered (88-89)
  Domains in SCOPe 2.08: d3ggta_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus type 1 (BRU ISOLATE) [TaxId:11686]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367 (0-98)
    • engineered (11-12)
    • engineered (14)
    • engineered (19)
    • engineered (31-32)
    • engineered (42)
    • engineered (53-54)
    • engineered (61-62)
    • engineered (70-72)
    • engineered (76)
    • engineered (81)
    • engineered (83)
    • engineered (88-89)
  Domains in SCOPe 2.08: d3ggtb_
• Heterogens: 017, BME, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ggtA (A:)
  pqitlwqrplvvvkvggqlmealldtgaddtifeemslpgrwtpkmiggiggflnvrqyd
  qvpieicghkvvstvligptplnvigrnvmtqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ggtB (B:)
  pqitlwqrplvvvkvggqlmealldtgaddtifeemslpgrwtpkmiggiggflnvrqyd
  qvpieicghkvvstvligptplnvigrnvmtqigctlnf