PDB entry 3ggs

View 3ggs on RCSB PDB site
Description: Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoro-2'-deoxyadenosine
Class: transferase
Keywords: enzyme-prodrug complex, Disease mutation, Glycosyltransferase, Transferase
Deposited on 2009-03-02, released 2009-04-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491
      • engineered (222)
      • engineered (264)
    Domains in SCOPe 2.08: d3ggsa_
  • Chain 'B':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (22-End)
      • engineered (222)
      • engineered (264)
    Domains in SCOPe 2.08: d3ggsb_
  • Chain 'C':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491
      • engineered (222)
      • engineered (264)
    Domains in SCOPe 2.08: d3ggsc_
  • Heterogens: 2FD, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ggsA (A:)
ketaaakferqhmdsggggsghmengytyedykntaewllshtkhrpqvaiicgsglggl
tdkltqaqifdygeipnfprstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtf
pvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdr
fpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfqtvaecrvlqklgadavg
mstvpevivarhcglrvfgfslitdkvimdyeslekanheevlaagkqaaqkleqfvsil
masiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3ggsA (A:)
ngytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdygeipnfprstvp
ghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnp
kfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqmg
eqrelqegtyvmvagpsfqtvaecrvlqklgadavgmstvpevivarhcglrvfgfslit
dkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ggsB (B:)
ketaaakferqhmdsggggsghmengytyedykntaewllshtkhrpqvaiicgsglggl
tdkltqaqifdygeipnfprstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtf
pvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdr
fpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfqtvaecrvlqklgadavg
mstvpevivarhcglrvfgfslitdkvimdyeslekanheevlaagkqaaqkleqfvsil
masiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3ggsB (B:)
mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdygeipnfprst
vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkq
mgeqrelqegtyvmvagpsfqtvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
itdkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ggsC (C:)
ketaaakferqhmdsggggsghmengytyedykntaewllshtkhrpqvaiicgsglggl
tdkltqaqifdygeipnfprstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtf
pvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdr
fpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfqtvaecrvlqklgadavg
mstvpevivarhcglrvfgfslitdkvimdyeslekanheevlaagkqaaqkleqfvsil
masiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3ggsC (C:)
ngytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdygeipnfprstag
rlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfev
gdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqre
lqegtyvmvagpsfqtvaecrvlqklgadavgmstvpevivarhcglrvfgfslitdkvi
mdyeslekanheevlaagkqaaqkleqfvsilmasiplp