PDB entry 3ggj

View 3ggj on RCSB PDB site
Description: Human hypoxanthine-guanine phosphoribosyltransferase in complex with 9-(2-phosphonoethoxyethyl)guanine
Class: transferase
Keywords: purine salvage, anti-malarial chemotherapeutic, acyclic nucleoside phosphonate, Disease mutation, Glycosyltransferase, Gout, Magnesium, Metal-binding, Transferase
Deposited on 2009-02-28, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.239
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HPRT, HPRT1, HPT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ggja_
  • Chain 'B':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HPRT, HPRT1, HPT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ggjb_
  • Heterogens: 25H, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ggjA (A:)
atrspgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemgghh
ivalcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstgdikviggdd
lstltgknvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgf
eipdkfvvgyaldyneyfrdlnhvcvisetgkakyka

    Sequence, based on observed residues (ATOM records): (download) 
    >3ggjA (A:)
spgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemgghhiva
lcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstgdikviggddlst
ltgknvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgfeip
dkfvvgyaldyneyfrdlnhvcvisetgkakyka

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ggjB (B:)
atrspgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemgghh
ivalcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstgdikviggdd
lstltgknvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgf
eipdkfvvgyaldyneyfrdlnhvcvisetgkakyka

    Sequence, based on observed residues (ATOM records): (download) 
    >3ggjB (B:)
rspgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemgghiva
lcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycnqsgdikvigddlstltg
knvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgfeipdkf
vvgyaldyneyfrdlnhvcvisetgkakyka