PDB entry 3gep

View 3gep on RCSB PDB site
Description: Human hypoxanthine guanine phosphoribosyltranserfase in complex with (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine
Class: transferase
Keywords: phosphoribosyltransferase, acyclic nucleoside phosphonate, purine salvage pathway, malarial chemotherapeutic, Acetylation, Cytoplasm, Disease mutation, Glycosyltransferase, Gout, Magnesium, Metal-binding, Purine salvage, Transferase
Deposited on 2009-02-25, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-08-18, with a file datestamp of 2009-08-14.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.25
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HPRT, HPRT1, HPT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3gepa_
  • Chain 'B':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: HPRT, HPRT1, HPT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3gepb_
  • Heterogens: 24H, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gepA (A:)
atrspgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemgghh
ivalcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstgdikviggdd
lstltgknvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgf
eipdkfvvgyaldyneyfrdlnhvcvisetgkakyka

    Sequence, based on observed residues (ATOM records): (download) 
    >3gepA (A:)
rspgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemgghhiv
alcvlkggykffadlldyikalnrnsdrsipmtvdfirlksdqstgdikviggddlstlt
gknvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgfeipdk
fvvgyaldyneyfrdlnhvcvisetgkakyka

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3gepB (B:)
atrspgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemgghh
ivalcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstgdikviggdd
lstltgknvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgf
eipdkfvvgyaldyneyfrdlnhvcvisetgkakyka

    Sequence, based on observed residues (ATOM records): (download) 
    >3gepB (B:)
rspgvvisddepgydldlfcipnhyaedlervfiphglimdrterlardvmkemhivalc
vlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstgdikviggdlstltg
knvlivediidtgktmqtllslvrqynpkmvkvasllvkrtprsvgykpdfvgfeipdkf
vvgyaldyneyfrdlnhvcvisetgkakyka