PDB entry 3gen
View 3gen on RCSB PDB site
Description: The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound
Class: transferase
Keywords: Bruton's tyrosine kinase, 4-Amino-5-(4-phenoxyphenyl)-5H-pyrrolo[3, 2-d]pyrimidin-7-yl-cyclopentane, TEC-family, complex, Acetylation, ATP-binding, Cytoplasm, Disease mutation, Kinase, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, SH2 domain, SH3 domain, Transferase, Tyrosine-protein kinase, Zinc, Zinc-finger
Deposited on
2009-02-25, released
2010-01-19
The last revision prior to the SCOPe 2.05 freeze date was dated
2010-03-09, with a file datestamp of
2010-03-05.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.195
AEROSPACI score: 0.58
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase BTK
Species: Homo sapiens [TaxId:9606]
Gene: AGMX1, ATK, BPK, BTK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3gena_ - Heterogens: B43, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3genA (A:)
gplgsknapstaglgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegs
msedefieeakvmmnlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtq
qllemckdvceameyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvg
skfpvrwsppevlmyskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrl
yrphlasekvytimyscwhekaderptfkillsnildvmdees
Sequence, based on observed residues (ATOM records): (download)
>3genA (A:)
ygsweidpkdltflkelgfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlsh
eklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyles
kqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskf
ssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscw
hekaderptfkillsnildvmdee