PDB entry 3gcw

View 3gcw on RCSB PDB site
Description: pcsk9:egfa(h306y)
Class: protein binding
Keywords: PCSK9, LDL receptor, Autocatalytic cleavage, Cholesterol metabolism, Disease mutation, Glycoprotein, Hydrolase, Lipid metabolism, Phosphoprotein, Protease, Secreted, Serine protease, Steroid metabolism, Zymogen, Coated pit, EGF-like domain, Endocytosis, Host-virus interaction, LDL, Lipid transport, Membrane, Receptor, Transmembrane, Transport, PROTEIN BINDING
Deposited on 2009-02-22, released 2009-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.236
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3gcwa1
  • Chain 'E':
    Compound: low-density lipoprotein receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: LDLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01130 (3-End)
      • expression tag (2)
      • engineered (16)
    Domains in SCOPe 2.08: d3gcwe1, d3gcwe2
  • Chain 'P':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CA

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gcwA (A:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgag
wqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcrah
nafggegvyaiarccllpqancsvhtappaeasmgtrvhchqqghvltgcsshwevedlg
thkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqeqvtvaceegwtl
tgcsalpgtshvlgayavdntcvvrsrdvsttgstseeavtavaiccrsrhlaqasqelq

    Sequence, based on observed residues (ATOM records): (download) 
    >3gcwA (A:)
sipwnleritppryradeyqgslvevylldtsiqsdhreiegrvmvtdfenvpeeaskcd
shgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplv
vllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdq
pvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaep
eltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthwqlfcrtvwsahsgp
trmataiarcapdeellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiarcc
llpqhapgleckvkehgipapqeqvtvaceegwtltgcsalpgtshvlgayavdntcvvr
sravtavaiccrsr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3gcwE (E:)
gamgtnecldnnggcsyvcndlkigyeclcpdgfqlvaqrrcedidecqdpdtcsqlcvn
leggykcqceegfqldphtkack

    Sequence, based on observed residues (ATOM records): (download) 
    >3gcwE (E:)
mgtnecldnnggcsyvcndlkigyeclcpdgfqlvaqrrce

  • Chain 'P':
    No sequence available.