PDB entry 3gcs
View 3gcs on RCSB PDB site
Description: Human P38 MAP kinase in complex with Sorafenib
Class: transferase
Keywords: DFG-out, Type II, BAY439006, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase
Deposited on
2009-02-22, released
2009-06-09
The last revision prior to the SCOPe 2.01 freeze date was dated
2009-09-29, with a file datestamp of
2009-09-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.204
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 14
Species: Homo sapiens [TaxId:9606]
Gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2
Database cross-references and differences (RAF-indexed):
- Uniprot Q16539
- engineered (118)
- engineered (161)
- engineered (326)
Domains in SCOPe 2.01: d3gcsa_ - Heterogens: BAX, BOG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3gcsA (A:)
gsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfq
siihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivksq
kltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedselkildfglcrhtddemt
gyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvg
tpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaa
qalahayfaqyhdpddepvadpydqslesrdllidewksltydevisfvpppldqeemes
Sequence, based on observed residues (ATOM records): (download)
>3gcsA (A:)
rptfyrqelnktiwevperyqnlspvgygsvcaafdtktglrvavkklsrpfqsiihakr
tyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivksqkltddhv
qfliyqilrglkyihsadiihrdlkpsnlavnedselkildfgtrwyrapeimlnwmhyn
qtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesarnyiqs
ltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvad
pydqslesrdllidewksltydevisfvppp