PDB entry 3gc6

View 3gc6 on RCSB PDB site
Description: Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.
Class: hydrolase
Keywords: CD38, cyclic ADP ribose, ecto-ADP-ribosyl cyclase, Glycosidase, Hydrolase
Deposited on 2009-02-21, released 2010-03-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.51 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ecto-NAD+ glycohydrolase (CD38 molecule)
    Species: Bos taurus [TaxId:9913]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9TTF5
      • engineered (186)
    Domains in SCOPe 2.08: d3gc6a_
  • Chain 'B':
    Compound: Ecto-NAD+ glycohydrolase (CD38 molecule)
    Species: Bos taurus [TaxId:9913]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9TTF5
      • engineered (186)
    Domains in SCOPe 2.08: d3gc6b_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3gc6A (A:)
    ykwhysglnrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdp
    ckatkedynslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrw
    cgepgssdlniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsm
    sifgrvqapnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsr
    dqflqrs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3gc6A (A:)
    ysglnrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdpckat
    kedynslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrwcgep
    gssdlniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsmsifg
    rvqapnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsrdqfl
    qr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3gc6B (B:)
    ykwhysglnrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdp
    ckatkedynslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrw
    cgepgssdlniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsm
    sifgrvqapnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsr
    dqflqrs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3gc6B (B:)
    lnrwhgagstadfqkiiqercdtytqtirpgsrsrncqairqafmsafiskdpckatked
    ynslinlapptvpcgqqvfwsktkelaheyakrrrlmtledtllgyladglrwcgepgss
    dlniwscpdwrkdcrtnylsvfwevlserfaesacntvrvvlngslenafdsmsifgrvq
    apnlrpqveleawlvhdtgkppsdscsgssirklksildgrnvkfrcmdnlsrdqfl