PDB entry 3gb9

View 3gb9 on RCSB PDB site
Description: Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoroadenine
Class: transferase
Keywords: Enzyme-product complex, Disease mutation, Glycosyltransferase, Transferase
Deposited on 2009-02-19, released 2009-04-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491
      • engineered (222)
      • engineered (264)
    Domains in SCOPe 2.07: d3gb9a_
  • Chain 'B':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (22-End)
      • expression tag (20-21)
      • engineered (222)
      • engineered (264)
    Domains in SCOPe 2.07: d3gb9b1, d3gb9b2
  • Chain 'C':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (22-End)
      • engineered (222)
      • engineered (264)
    Domains in SCOPe 2.07: d3gb9c_
  • Heterogens: A2F, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gb9A (A:)
ketaaakferqhmdsggggsghmengytyedykntaewllshtkhrpqvaiicgsglggl
tdkltqaqifdygeipnfprstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtf
pvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdr
fpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfqtvaecrvlqklgadavg
mstvpevivarhcglrvfgfslitdkvimdyeslekanheevlaagkqaaqkleqfvsil
masiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3gb9A (A:)
ngytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdygeipnfprstvp
ghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnp
kfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqmg
eqrelqegtyvmvagpsfqtvaecrvlqklgadavgmstvpevivarhcglrvfgfslit
dkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3gb9B (B:)
ketaaakferqhmdsggggsghmengytyedykntaewllshtkhrpqvaiicgsglggl
tdkltqaqifdygeipnfprstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtf
pvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdr
fpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfqtvaecrvlqklgadavg
mstvpevivarhcglrvfgfslitdkvimdyeslekanheevlaagkqaaqkleqfvsil
masiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3gb9B (B:)
ghmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdygeipnfpr
stgrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpk
fevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqmge
qrelqegtyvmvagpsfqtvaecrvlqklgadavgmstvpevivarhcglrvfgfslitd
kvimdyeagkqaaqkleqfvsilmasiplp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3gb9C (C:)
ketaaakferqhmdsggggsghmengytyedykntaewllshtkhrpqvaiicgsglggl
tdkltqaqifdygeipnfprstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtf
pvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdr
fpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfqtvaecrvlqklgadavg
mstvpevivarhcglrvfgfslitdkvimdyeslekanheevlaagkqaaqkleqfvsil
masiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3gb9C (C:)
mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdygeipnfprst
agrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkf
evgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqmgeq
relqegtyvmvagpsfqtvaecrvlqklgadavgmstvpevivarhcglrvfgfslitdk
vimdyesvlaagkqaaqkleqfvsilmasiplp