PDB entry 3g9e
View 3g9e on RCSB PDB site
Description: Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type II diabetes
Class: transcription/transferase
Keywords: NUCLEAR RECEPTOR, TRANSCRIPTION FACTOR, DIABETES, Activator, Alternative splicing, Diabetes mellitus, Disease mutation, DNA-binding, Metal-binding, Nucleus, Obesity, Phosphoprotein, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger, Acyltransferase, Chromosomal rearrangement, Proto-oncogene, Transferase, Ubl conjugation, TRANSCRIPTION/TRANSFERASE COMPLEX
Deposited on
2009-02-13, released
2009-06-02
The last revision prior to the SCOPe 2.07 freeze date was dated
2009-06-02, with a file datestamp of
2009-05-29.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.2
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Peroxisome proliferator-activated receptor gamma
Species: Homo sapiens [TaxId:9606]
Gene: PPARG, NR1C3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g9ea_ - Chain 'B':
Compound: Nuclear receptor coactivator 1
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: RO7, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3g9eA (A:)
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheii
ytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlai
fiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqiv
tehvqllqvikktetdmslhpllqeiykdly
Sequence, based on observed residues (ATOM records): (download)
>3g9eA (A:)
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkkevai
rifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgv
lisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpg
llnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikkt
etdmslhpllqeiykdly
- Chain 'B':
No sequence available.