PDB entry 3g7v

View 3g7v on RCSB PDB site
Description: islet amyloid polypeptide (iapp or amylin) fused to maltose binding protein
Deposited on 2009-02-10, released 2009-06-23
The last revision was dated 2021-10-20, with a file datestamp of 2021-10-15.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein
    Species: Homo sapiens [TaxId:9606]
    Gene: malE, b4034, JW3994, IAPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AEX9 (1-366)
      • initiating methionine (0)
      • engineered mutation (359)
      • engineered mutation (362-363)
      • linker (367-369)
      • linker (0)
    • Uniprot P10997 (371-406)
      • linker (370)
  • Chain 'B':
    Compound: Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein
    Species: Homo sapiens [TaxId:9606]
    Gene: malE, b4034, JW3994, IAPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AEX9 (1-366)
      • initiating methionine (0)
      • engineered mutation (359)
      • engineered mutation (362-363)
      • linker (367-369)
      • linker (0)
    • Uniprot P10997 (371-406)
      • linker (370)
  • Chain 'C':
    Compound: Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein
    Species: Homo sapiens [TaxId:9606]
    Gene: malE, b4034, JW3994, IAPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AEX9 (1-366)
      • initiating methionine (0)
      • engineered mutation (359)
      • engineered mutation (362-363)
      • linker (367-369)
      • linker (0)
    • Uniprot P10997 (371-406)
      • linker (370)
  • Chain 'D':
    Compound: Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein
    Species: Homo sapiens [TaxId:9606]
    Gene: malE, b4034, JW3994, IAPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AEX9 (1-366)
      • initiating methionine (0)
      • engineered mutation (359)
      • engineered mutation (362-363)
      • linker (367-369)
      • linker (0)
    • Uniprot P10997 (371-406)
      • linker (370)
  • Heterogens: SO4, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3g7vA (A:)
mkieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdi
ifwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynk
dllpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydik
dvgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtsk
vnygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkpl
gavalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvda
alaaaqtnaaakcntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >3g7vA (A:)
kieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdii
fwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynkd
llpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydikd
vgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtskv
nygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkplg
avalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvdaa
laaaqtnaaakcntatcatqrlanflvhssnnfgailss

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3g7vB (B:)
mkieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdi
ifwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynk
dllpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydik
dvgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtsk
vnygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkpl
gavalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvda
alaaaqtnaaakcntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >3g7vB (B:)
kieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdii
fwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynkd
llpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydikd
vgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtskv
nygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkplg
avalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvdaa
laaaqtnaaakcntatcatqrlanflvhssnnfgailss

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3g7vC (C:)
mkieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdi
ifwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynk
dllpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydik
dvgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtsk
vnygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkpl
gavalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvda
alaaaqtnaaakcntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >3g7vC (C:)
kieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdii
fwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynkd
llpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydikd
vgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtskv
nygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkplg
avalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvdaa
laaaqtnaaakcntatcatqrlanflvhssnnfgail

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3g7vD (D:)
mkieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdi
ifwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynk
dllpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydik
dvgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtsk
vnygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkpl
gavalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvda
alaaaqtnaaakcntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >3g7vD (D:)
kieegklviwingdkgynglaevgkkfekdtgikvtvehpdkleekfpqvaatgdgpdii
fwahdrfggyaqsgllaeitpdkafqdklypftwdavryngkliaypiavealsliynkd
llpnppktweeipaldkelkakgksalmfnlqepyftwpliaadggyafkyengkydikd
vgvdnagakagltflvdliknkhmnadtdysiaeaafnkgetamtingpwawsnidtskv
nygvtvlptfkgqpskpfvgvlsaginaaspnkelakeflenylltdegleavnkdkplg
avalksyeeelakdpriaatmenaqkgeimpnipqmsafwyavrtavinaasgrqtvdaa
laaaqtnaaakcntatcatqrlanflvhssnnfgail