PDB entry 3g70

View 3g70 on RCSB PDB site
Description: Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors
Class: hydrolase
Keywords: human renin, Aspartyl protease, Cleavage on pair of basic residues, Disease mutation, Glycoprotein, Hydrolase, Membrane, Protease, Secreted, Zymogen
Deposited on 2009-02-09, released 2009-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00797 (Start-339)
      • expression tag (340)
    Domains in SCOPe 2.08: d3g70a1, d3g70a2
  • Chain 'B':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00797 (0-339)
      • expression tag (340)
    Domains in SCOPe 2.08: d3g70b1, d3g70b2
  • Heterogens: A5T, DMS, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g70A (A:)
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlgg
sdpqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssie
klmealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlai
hamdippptgptwalgatfirkfytefdrrnnrigfalarh

    Sequence, based on observed residues (ATOM records): (download) 
    >3g70A (A:)
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsslggqivlggsdpqhye
gnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealg
akkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdipp
ptgptwalgatfirkfytefdrrnnrigfalarh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g70B (B:)
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlgg
sdpqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssie
klmealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlai
hamdippptgptwalgatfirkfytefdrrnnrigfalarh

    Sequence, based on observed residues (ATOM records): (download) 
    >3g70B (B:)
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsslggqivlggsdpq
hyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklme
algakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamd
ippptgptwalgatfirkfytefdrrnnrigfalarh