PDB entry 3g5u

View 3g5u on RCSB PDB site
Description: structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
Deposited on 2009-02-05, released 2009-03-24
The last revision was dated 2021-10-20, with a file datestamp of 2021-10-15.
Experiment type: XRAY
Resolution: 3.8 Å
R-factor: 0.306
AEROSPACI score: 0 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Multidrug resistance protein 1a
    Species: Mus musculus [TaxId:10090]
    Gene: Abcb1a, mCG_1178
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5I1Y5 (0-1275)
      • engineered mutation (951)
      • expression tag (1276-1283)
  • Chain 'B':
    Compound: Multidrug resistance protein 1a
    Species: Mus musculus [TaxId:10090]
    Gene: Abcb1a, mCG_1178
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5I1Y5 (0-1275)
      • engineered mutation (951)
      • expression tag (1276-1283)
  • Heterogens: HG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3g5uA (A:)
meleedlkgradknfskmgkkskkekkekkpavsvltmfryagwldrlymlvgtlaaiih
gvalplmmlifgdmtdsfasvgnvsknstnmseadkramfakleeemttyayyytgigag
vlivayiqvsfwclaagrqihkirqkffhaimnqeigwfdvhdvgelntrltddvskine
gigdkigmffqamatffggfiigftrgwkltlvilaispvlglsagiwakilssftdkel
hayakagavaeevlaairtviafggqkkelerynnnleeakrlgikkaitanismgaafl
liyasyalafwygtslviskeysigqvltvffsvligafsvgqaspnieafanargaaye
vfkiidnkpsidsfsksghkpdniqgnlefknihfsypsrkevqilkglnlkvksgqtva
lvgnsgcgksttvqlmqrlydpldgmvsidgqdirtinvrylreiigvvsqepvlfatti
aenirygredvtmdeiekavkeanaydfimklphqfdtlvgergaqlsggqkqriaiara
lvrnpkillldeatsaldteseavvqaaldkaregrttiviahrlstvrnadviagfdgg
viveqgnhdelmrekgiyfklvmtqtagneielgneackskdeidnldmsskdsgsslir
rrstrksicgphdqdrklstkealdedvppasfwrilklnstewpyfvvgifcaiinggl
qpafsvifskvvgvftnggppetqrqnsnlfsllflilgiisfitfflqgftfgkageil
tkrlrymvfksmlrqdvswfddpknttgalttrlandaaqvkgatgsrlavifqnianlg
tgiiisliygwqltllllaivpiiaiagvvemkmlsgqalkdkkelegsgkiateaienf
rtvvsltreqkfetmyaqslqipyrnamkkahvfgitfsftqammyfsyaaafrfgaylv
tqqlmtfenvllvfsaivfgamavgqvssfapdyakatvsashiiriiektpeidsystq
glkpnmlegnvqfsgvvfnyptrpsipvlqglslevkkgqtlalvgssgcgkstvvqlle
rfydpmagsvfldgkeikqlnvqwlraqlgivsqepilfdcsiaeniaygdnsrvvsyee
ivraakeanihqfidslpdkyntrvgdkgtqlsggqkqriaiaralvrqphillldeats
aldtesekvvqealdkaregrtciviahrlstiqnadlivviqngkvkehgthqqllaqk
giyfsmvsvqagakrsyvhhhhhh

    Sequence, based on observed residues (ATOM records):
    >3g5uA (A:)
vsvltmfryagwldrlymlvgtlaaiihgvalplmmlifgdmtdsfasvgnvsknstnms
eadkramfakleeemttyayyytgigagvlivayiqvsfwclaagrqihkirqkffhaim
nqeigwfdvhdvgelntrltddvskinegigdkigmffqamatffggfiigftrgwkltl
vilaispvlglsagiwakilssftdkelhayakagavaeevlaairtviafggqkkeler
ynnnleeakrlgikkaitanismgaaflliyasyalafwygtslviskeysigqvltvff
svligafsvgqaspnieafanargaayevfkiidnkpsidsfsksghkpdniqgnlefkn
ihfsypsrkevqilkglnlkvksgqtvalvgnsgcgksttvqlmqrlydpldgmvsidgq
dirtinvrylreiigvvsqepvlfattiaenirygredvtmdeiekavkeanaydfimkl
phqfdtlvgergaqlsggqkqriaiaralvrnpkillldeatsaldteseavvqaaldka
regrttiviahrlstvrnadviagfdggviveqgnhdelmrekgiyfklvmtqtldedvp
pasfwrilklnstewpyfvvgifcaiingglqpafsvifskvvgvftnggppetqrqnsn
lfsllflilgiisfitfflqgftfgkageiltkrlrymvfksmlrqdvswfddpknttga
lttrlandaaqvkgatgsrlavifqnianlgtgiiisliygwqltllllaivpiiaiagv
vemkmlsgqalkdkkelegsgkiateaienfrtvvsltreqkfetmyaqslqipyrnamk
kahvfgitfsftqammyfsyaaafrfgaylvtqqlmtfenvllvfsaivfgamavgqvss
fapdyakatvsashiiriiektpeidsystqglkpnmlegnvqfsgvvfnyptrpsipvl
qglslevkkgqtlalvgssgcgkstvvqllerfydpmagsvfldgkeikqlnvqwlraql
givsqepilfdcsiaeniaygdnsrvvsyeeivraakeanihqfidslpdkyntrvgdkg
tqlsggqkqriaiaralvrqphillldeatsaldtesekvvqealdkaregrtciviahr
lstiqnadlivviqngkvkehgthqqllaqkgiyfsmvsvqa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3g5uB (B:)
meleedlkgradknfskmgkkskkekkekkpavsvltmfryagwldrlymlvgtlaaiih
gvalplmmlifgdmtdsfasvgnvsknstnmseadkramfakleeemttyayyytgigag
vlivayiqvsfwclaagrqihkirqkffhaimnqeigwfdvhdvgelntrltddvskine
gigdkigmffqamatffggfiigftrgwkltlvilaispvlglsagiwakilssftdkel
hayakagavaeevlaairtviafggqkkelerynnnleeakrlgikkaitanismgaafl
liyasyalafwygtslviskeysigqvltvffsvligafsvgqaspnieafanargaaye
vfkiidnkpsidsfsksghkpdniqgnlefknihfsypsrkevqilkglnlkvksgqtva
lvgnsgcgksttvqlmqrlydpldgmvsidgqdirtinvrylreiigvvsqepvlfatti
aenirygredvtmdeiekavkeanaydfimklphqfdtlvgergaqlsggqkqriaiara
lvrnpkillldeatsaldteseavvqaaldkaregrttiviahrlstvrnadviagfdgg
viveqgnhdelmrekgiyfklvmtqtagneielgneackskdeidnldmsskdsgsslir
rrstrksicgphdqdrklstkealdedvppasfwrilklnstewpyfvvgifcaiinggl
qpafsvifskvvgvftnggppetqrqnsnlfsllflilgiisfitfflqgftfgkageil
tkrlrymvfksmlrqdvswfddpknttgalttrlandaaqvkgatgsrlavifqnianlg
tgiiisliygwqltllllaivpiiaiagvvemkmlsgqalkdkkelegsgkiateaienf
rtvvsltreqkfetmyaqslqipyrnamkkahvfgitfsftqammyfsyaaafrfgaylv
tqqlmtfenvllvfsaivfgamavgqvssfapdyakatvsashiiriiektpeidsystq
glkpnmlegnvqfsgvvfnyptrpsipvlqglslevkkgqtlalvgssgcgkstvvqlle
rfydpmagsvfldgkeikqlnvqwlraqlgivsqepilfdcsiaeniaygdnsrvvsyee
ivraakeanihqfidslpdkyntrvgdkgtqlsggqkqriaiaralvrqphillldeats
aldtesekvvqealdkaregrtciviahrlstiqnadlivviqngkvkehgthqqllaqk
giyfsmvsvqagakrsyvhhhhhh

    Sequence, based on observed residues (ATOM records):
    >3g5uB (B:)
vsvltmfryagwldrlymlvgtlaaiihgvalplmmlifgdmtdsfasvgnvsknstnms
eadkramfakleeemttyayyytgigagvlivayiqvsfwclaagrqihkirqkffhaim
nqeigwfdvhdvgelntrltddvskinegigdkigmffqamatffggfiigftrgwkltl
vilaispvlglsagiwakilssftdkelhayakagavaeevlaairtviafggqkkeler
ynnnleeakrlgikkaitanismgaaflliyasyalafwygtslviskeysigqvltvff
svligafsvgqaspnieafanargaayevfkiidnkpsidsfsksghkpdniqgnlefkn
ihfsypsrkevqilkglnlkvksgqtvalvgnsgcgksttvqlmqrlydpldgmvsidgq
dirtinvrylreiigvvsqepvlfattiaenirygredvtmdeiekavkeanaydfimkl
phqfdtlvgergaqlsggqkqriaiaralvrnpkillldeatsaldteseavvqaaldka
regrttiviahrlstvrnadviagfdggviveqgnhdelmrekgiyfklvmtqtldedvp
pasfwrilklnstewpyfvvgifcaiingglqpafsvifskvvgvftnggppetqrqnsn
lfsllflilgiisfitfflqgftfgkageiltkrlrymvfksmlrqdvswfddpknttga
lttrlandaaqvkgatgsrlavifqnianlgtgiiisliygwqltllllaivpiiaiagv
vemkmlsgqalkdkkelegsgkiateaienfrtvvsltreqkfetmyaqslqipyrnamk
kahvfgitfsftqammyfsyaaafrfgaylvtqqlmtfenvllvfsaivfgamavgqvss
fapdyakatvsashiiriiektpeidsystqglkpnmlegnvqfsgvvfnyptrpsipvl
qglslevkkgqtlalvgssgcgkstvvqllerfydpmagsvfldgkeikqlnvqwlraql
givsqepilfdcsiaeniaygdnsrvvsyeeivraakeanihqfidslpdkyntrvgdkg
tqlsggqkqriaiaralvrqphillldeatsaldtesekvvqealdkaregrtciviahr
lstiqnadlivviqngkvkehgthqqllaqkgiyfsmvsvqa