PDB entry 3g5n

View 3g5n on RCSB PDB site
Description: Triple ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole
Class: oxidoreductase
Keywords: P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4, CYP LM2, Endoplasmic reticulum, Heme, Iron, Membrane, Metal-binding, Microsome, Phosphoprotein, Polymorphism
Deposited on 2009-02-05, released 2009-05-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-06-09, with a file datestamp of 2010-06-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.22
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2B4
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: CYP2B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00178 (Start-471)
      • engineered (7)
      • engineered (9)
      • see remark 999 (201)
      • engineered (206)
      • expression tag (472-473)
    Domains in SCOPe 2.08: d3g5na1, d3g5na2
  • Chain 'B':
    Compound: Cytochrome P450 2B4
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: CYP2B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00178 (Start-471)
      • engineered (9)
      • see remark 999 (201)
      • engineered (206)
      • expression tag (472)
    Domains in SCOPe 2.08: d3g5nb1, d3g5nb2
  • Chain 'C':
    Compound: Cytochrome P450 2B4
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: CYP2B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00178 (Start-471)
      • engineered (6-7)
      • engineered (9)
      • see remark 999 (201)
      • engineered (206)
      • expression tag (472)
    Domains in SCOPe 2.08: d3g5nc1, d3g5nc2
  • Chain 'D':
    Compound: Cytochrome P450 2B4
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: CYP2B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00178 (Start-471)
      • engineered (9)
      • see remark 999 (201)
      • engineered (206)
      • expression tag (472)
    Domains in SCOPe 2.08: d3g5nd1, d3g5nd2
  • Heterogens: HEM, PB2, CM5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g5nA (A:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3g5nA (A:)
kgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdaire
alvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdkrsveeriqeea
rclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfslis
sfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidvyll
rmekdfhhqnliltvlslffagtettsttlrygfllmlkyphvtervqkeieqvigshrp
palddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipkntevfpvlssalh
dpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelflffttilqnf
siaspvppedidltpresgvgnvppsyqirflarhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g5nB (B:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3g5nB (B:)
gklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdairea
lvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdkrsveeriqeear
clveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfsliss
fssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidvyllr
mehhqnliltvlslffagtettsttlrygfllmlkyphvtervqkeieqvigshrppald
drakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipkntevfpvlssalhdpry
fetpntfnpghfldangalkrnegfmpfslgkriclgegiartelflffttilqnfsias
pvppedidltpresgvgnvppsyqirflarh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3g5nC (C:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3g5nC (C:)
skgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdair
ealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdkrsveeriqee
arclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfsli
ssfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidvyl
lrmehqnliltvlslffagtettsttlrygfllmlkyphvtervqkeieqvigshrppal
ddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipkntevfpvlssalhdpr
yfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelflffttilqnfsia
spvppedidltpresgvgnvppsyqirflarh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3g5nD (D:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3g5nD (D:)
gklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdairea
lvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfrsveeriqeear
clveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfsliss
fssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidvyllr
mehhqnliltvlslffagtettsttlrygfllmlkyphvtervqkeieqvigshrppald
drakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipkntevfpvlssalhdpry
fetpntfnpghfldangalkrnegfmpfslgkriclgegiartelflffttilqnfsias
pvppedidltpresgvgnvppsyqirflarh