PDB entry 3g4a

View 3g4a on RCSB PDB site
Description: Crystal structure of flavine dependant thymidylate synthase S88A mutant from Thermotoga maritima at 1.95 angstrom resolution
Class: transferase
Keywords: FDTS, thyX, S88A mutation, dUMP complex, FAD, Flavoprotein, Methyltransferase, Nucleotide biosynthesis, Transferase
Deposited on 2009-02-03, released 2009-04-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.187
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima MSB8 [TaxId:243274]
    Gene: thy1, thyX, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • leader sequence (10-11)
      • engineered (99)
    Domains in SCOPe 2.08: d3g4aa1, d3g4aa2
  • Chain 'B':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima MSB8 [TaxId:243274]
    Gene: thy1, thyX, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • leader sequence (11)
      • engineered (99)
    Domains in SCOPe 2.08: d3g4ab1, d3g4ab2
  • Chain 'C':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima MSB8 [TaxId:243274]
    Gene: thy1, thyX, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • engineered (99)
    Domains in SCOPe 2.08: d3g4ac_
  • Chain 'D':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima MSB8 [TaxId:243274]
    Gene: thy1, thyX, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • engineered (99)
    Domains in SCOPe 2.08: d3g4ad_
  • Heterogens: FAD, UMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g4aA (A:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelagrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >3g4aA (A:)
hhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieylmkhghetpfe
hivftfhvkapifvarqwfrhriasynelagrysklsyefyipsperlegykttipperv
tekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradsh
aqweiqqyalaiarifkekcpwtfeaflkyaykgdilk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g4aB (B:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelagrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >3g4aB (B:)
hmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieylmkhghetpfeh
ivftfhvkapifvarqwfrhriasynelagrysklsyefyipsperlegykttippervt
ekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradsha
qweiqqyalaiarifkekcpwtfeaflkyaykgdilkevq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3g4aC (C:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelagrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >3g4aC (C:)
mkidildkgfvelvdvmgndlsavraarvsfkdeerdrhlieylmkhghetpfehivftf
hvkapifvarqwfrhriasynelagrysklsyefyipsperlegykttippervtekise
ivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradshaqweiq
qyalaiarifkekcpwtfeaflkyaykgdilkev

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3g4aD (D:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelagrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >3g4aD (D:)
mkidildkgfvelvdvmgndlsavraarvsfeerdrhlieylmkhghetpfehivftfhv
kapifvarqwfrhriasynelagrysklsyefyipsperlegykttippervtekiseiv
dkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradshaqweiqqy
alaiarifkekcpwtfeaflkyaykgdilkev