PDB entry 3g0u

View 3g0u on RCSB PDB site
Description: Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4
Class: Oxidoreductase
Keywords: beta-alpha-barrel, TIM-barrel, FAD, Flavoprotein, Membrane, Mitochondrion, Mitochondrion inner membrane, Oxidoreductase, Polymorphism, Pyrimidine biosynthesis, Transit peptide
Deposited on 2009-01-28, released 2009-06-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-06-09, with a file datestamp of 2009-06-05.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.171
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydroorotate dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3g0ua_
  • Heterogens: ORO, FMN, MDY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g0uA (A:)
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
igadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0uA (A:)
gderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgia
agfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgls
vvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvss
pntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkel
gidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvgg
vssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr
r