PDB entry 3g0g

View 3g0g on RCSB PDB site
Description: Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinone inhibitor 3
Class: hydrolase/hydrolase inhibitor
Keywords: DPP4, pyrimidinone, pyrimidindione, Aminopeptidase, Cell membrane, Glycoprotein, Hydrolase, Membrane, Protease, Secreted, Serine protease, Signal-anchor, Transmembrane, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2009-01-27, released 2010-02-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.212
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3g0ga1, d3g0ga2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (12-739)
      • expression tag (8-11)
    Domains in SCOPe 2.04: d3g0gb1, d3g0gb2
  • Chain 'C':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3g0gc1, d3g0gc2
  • Chain 'D':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3g0gd1, d3g0gd2
  • Heterogens: RUM, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g0gA (A:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0gA (A:)
ktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfdefghsi
ndysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvgh
klayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtf
layaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtna
tsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclva
rqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgtw
evigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfs
keakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnet
kfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrg
sgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgs
gsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyll
ihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqc
fslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g0gB (B:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0gB (B:)
hhhhsrktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfd
efghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvt
wspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalww
spngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsl
ssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgr
wnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctf
itkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqy
ysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldf
iilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiva
sfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvt
smvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfk
qveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythms
hfikqcfslp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3g0gC (C:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0gC (C:)
ktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfdefghsi
ndysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvgh
klayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtf
layaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtna
tsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclva
rqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgtw
evigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfs
keakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnet
kfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrg
sgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgs
gsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyll
ihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqc
fslp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3g0gD (D:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0gD (D:)
ktytltdylkntyrlklyslrwisdheylysindysispdgqfilleynyvkqwrhsyta
sydiyditeeripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyn
gitdwvyeeevfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpy
pkagavnptvkffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwl
rriqnysvmdicdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiis
neegyrhicyfqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiql
sdytkvtclscelnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvled
nsaldkmlqnvqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkad
tvfrlnwatylasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskm
gfvdnkriaiwgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptp
ednldhyrnstvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwyt
dedhgiasstahqhiythmshfikqcfslp