PDB entry 3fzh

View 3fzh on RCSB PDB site
Description: Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors
Class: chaperone
Keywords: HSP70, HSC70, BAG1, heat shock, chaperone, protein folding, adenosine, nucleotide, nucleotide exchange factor, small molecule inhibitor, ATP-binding, nucleotide-binding, stress response, apoptosis
Deposited on 2009-01-26, released 2009-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-03-31, with a file datestamp of 2009-03-27.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.218
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock cognate 71 kDa protein
    Species: Homo sapiens [TaxId:9606]
    Gene: HSPA8, HSC70, HSP73, HSPA10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3fzha1, d3fzha2
  • Chain 'B':
    Compound: BAG family molecular chaperone regulator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BAG1, HAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99933 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d3fzhb1, d3fzhb2
  • Heterogens: 3BH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fzhA (A:)
yfqgpavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqva
mnptntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevs
smvltkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlriineptaaa
iaygldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnh
fiaefkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitra
rfeelnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkeln
ksinpdeavaygaavqaails

    Sequence, based on observed residues (ATOM records): (download) 
    >3fzhA (A:)
pavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqvamnpt
ntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevssmvl
tkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlriineptaaaiayg
ldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnhfiae
fkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitrarfee
lnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkelnksin
pdeavaygaavqaails

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3fzhB (B:)
gnspqeevelkklkhleksvekiadqleelnkeltgiqqgflpkdlqaealckldrrvka
tieqfmkileeidtlilpenfkdsrlkrkglvkkvqaflaecdtveqnicqete

    Sequence, based on observed residues (ATOM records): (download) 
    >3fzhB (B:)
gnspqeevelkklkhleksvekiadqleelnkeltgiqqgflpkdlqaealckldrrvka
tieqfmkileeidtlilpenfkdsrlkrkglvkkvqaflaecdtveqnicq