PDB entry 3fw3

View 3fw3 on RCSB PDB site
Description: Crystal Structure of soluble domain of CA4 in complex with Dorzolamide
Class: lyase
Keywords: STRUCTURE-BASED DRUG DESIGN. SMALL MOLECULE COMPLEX. CO-CRYSTAL, Cell membrane, Disease mutation, Glycoprotein, GPI-anchor, Lipoprotein, Lyase, Membrane, Metal-binding, Polymorphism, Retinitis pigmentosa, Sensory transduction, Vision, Zinc
Deposited on 2009-01-16, released 2009-12-01
The last revision prior to the SCOPe 2.02 freeze date was dated 2010-05-12, with a file datestamp of 2010-05-07.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: 0.177
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CA4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3fw3a_
  • Chain 'B':
    Compound: Carbonic anhydrase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CA4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3fw3b_
  • Heterogens: ZN, ETS, GLC, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fw3A (A:)
aeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkk
qtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfame
mhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemstt
maesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyy
dkeqtvsmkdnvrplqqlgqrtviks

    Sequence, based on observed residues (ATOM records): (download) 
    >3fw3A (A:)
wcyevqaessnclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkqtwtvq
nnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamemhivhe
kekpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaesslldllpkeeklr
hyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqtvsmkdnvrplqq
lgqrtviks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3fw3B (B:)
aeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkk
qtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfame
mhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemstt
maesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyy
dkeqtvsmkdnvrplqqlgqrtviks

    Sequence, based on observed residues (ATOM records): (download) 
    >3fw3B (B:)
hwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkqtw
tvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamemhi
vhekeeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaesslldllp
keeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqtvsmkdn
vrplqqlgqrtviks