PDB entry 3fw3
View 3fw3 on RCSB PDB site
Description: Crystal Structure of soluble domain of CA4 in complex with Dorzolamide
Class: lyase
Keywords: STRUCTURE-BASED DRUG DESIGN. SMALL MOLECULE COMPLEX. CO-CRYSTAL, Cell membrane, Disease mutation, Glycoprotein, GPI-anchor, Lipoprotein, Lyase, Membrane, Metal-binding, Polymorphism, Retinitis pigmentosa, Sensory transduction, Vision, Zinc
Deposited on
2009-01-16, released
2009-12-01
The last revision prior to the SCOPe 2.01 freeze date was dated
2010-05-12, with a file datestamp of
2010-05-07.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: 0.177
AEROSPACI score: 0.55
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Carbonic anhydrase 4
Species: Homo sapiens [TaxId:9606]
Gene: CA4
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3fw3a_ - Chain 'B':
Compound: Carbonic anhydrase 4
Species: Homo sapiens [TaxId:9606]
Gene: CA4
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3fw3b_ - Heterogens: ZN, ETS, GLC, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3fw3A (A:)
aeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkk
qtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfame
mhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemstt
maesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyy
dkeqtvsmkdnvrplqqlgqrtviks
Sequence, based on observed residues (ATOM records): (download)
>3fw3A (A:)
wcyevqaessnclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkqtwtvq
nnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamemhivhe
kekpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaesslldllpkeeklr
hyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqtvsmkdnvrplqq
lgqrtviks
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3fw3B (B:)
aeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkk
qtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfame
mhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemstt
maesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyy
dkeqtvsmkdnvrplqqlgqrtviks
Sequence, based on observed residues (ATOM records): (download)
>3fw3B (B:)
hwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkqtw
tvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamemhi
vhekeeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaesslldllp
keeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqtvsmkdn
vrplqqlgqrtviks