PDB entry 3fup

View 3fup on RCSB PDB site
Description: Crystal structures of JAK1 and JAK2 inhibitor complexes
Class: transferase
Keywords: kinase, PTK domain, Protein-inhibitor complex, ATP-binding, Chromosomal rearrangement, Disease mutation, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2009-01-14, released 2009-02-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-05-05, with a file datestamp of 2009-05-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.182
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2, jak2 (amino acids 843 - 1132)
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (Start-292)
      • engineered (289)
    Domains in SCOPe 2.06: d3fupa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2, jak2 (amino acids 843 - 1132)
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (0-292)
      • engineered (289)
    Domains in SCOPe 2.06: d3fupb_
  • Heterogens: MI1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fupA (A:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3fupA (A:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknng
rlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3fupB (B:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3fupB (B:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickg
meylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyap
eslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellk
nngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag