PDB entry 3fsk

View 3fsk on RCSB PDB site
Description: P38 kinase crystal structure in complex with RO6257
Class: signaling protein, transferase
Keywords: P38; MAP KINASE; SERINE/THREONINE KINASE, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase, SIGNALING PROTEIN
Deposited on 2009-01-09, released 2009-12-22
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-12-22, with a file datestamp of 2009-12-18.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.207
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3fska_
  • Heterogens: RO6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fskA (A:)
mrgshhhhhhgsmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktgl
rvavkklsrpfqsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthl
mgadlnnivkcqkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkild
fglarhtddemtgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdh
idqlklilrlvgtpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekm
lvldsdkritaaqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisf
vpppldqeemes

    Sequence, based on observed residues (ATOM records): (download) 
    >3fskA (A:)
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfddemtgyvatrwyra
peimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkki
ssesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaq
yhdpddepvadpydqsfesrdllidewksltydevisfvppp