PDB entry 3fs6

View 3fs6 on RCSB PDB site
Description: Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
Class: oxidoreductase
Keywords: human wild type DHFR active site inhibitors, NADP, One-carbon metabolism, Oxidoreductase
Deposited on 2009-01-09, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-30, with a file datestamp of 2014-04-25.
Experiment type: XRAY
Resolution: 1.23 Å
R-factor: 0.246
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3fs6a_
  • Heterogens: DH1, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fs6A (A:)
mvgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfs
ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
evyeknd

    Sequence, based on observed residues (ATOM records): (download) 
    >3fs6A (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd