PDB entry 3fqx

View 3fqx on RCSB PDB site
Description: Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
Class: immune system
Keywords: IMMUNE SYSTEM, PHOSPHORYLATION, Glycoprotein, Immune response, Membrane, MHC I, Phosphoprotein, Transmembrane, Disease mutation, Immunoglobulin domain, Pyrrolidone carboxylic acid, Secreted, cancer, TCR, self-epitope
Deposited on 2009-01-07, released 2009-03-03
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.173
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3fqxb_
  • Chain 'C':
    Compound: phospho-peptide 1097-1105 from insulin receptor substrate 2 (IRS2): RVA(Sep)PTSGV
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 3FQX (0-8)
  • Heterogens: CD, MG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3fqxB (B:)
    qrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdws
    fyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.