PDB entry 3fqs

View 3fqs on RCSB PDB site
Description: Crystal structure of spleen tyrosine kinase complexed with R406
Class: transferase
Keywords: SYK, SPLEEN TYPROSINE KINASE, KINASE INHIBITOR, R406, R788, AMINO-PYRIMIDINE, ATP-binding, Host-virus interaction, Kinase, Nucleotide-binding, Phosphoprotein, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2009-01-07, released 2009-03-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43405 (Start-282)
      • expression tag (283-286)
    Domains in SCOPe 2.08: d3fqsa1, d3fqsa2
  • Heterogens: 585, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fqsA (A:)
maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdknii
elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvneghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3fqsA (A:)
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqql
dnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylee
snfvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfss
ksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwty
dvenrpgfaavelrlrnyyydvvneghh