PDB entry 3foe

View 3foe on RCSB PDB site
Description: Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
Class: isomerase/DNA
Keywords: quinolone, topoisomerase, DNA, protein-DNA cleavage complex, Streptococcus pneumoniae, clinafloxacin, Cell membrane, DNA-binding, Isomerase, Membrane, ATP-binding, Nucleotide-binding, ISOMERASE/DNA COMPLEX
Deposited on 2008-12-30, released 2009-02-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-06-23, with a file datestamp of 2009-06-19.
Experiment type: XRAY
Resolution: 4 Å
R-factor: 0.264
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA topoisomerase 4 subunit A
    Species: Streptococcus pneumoniae [TaxId:1313]
    Gene: parC, SP_0855
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3foea_
  • Chain 'B':
    Compound: DNA topoisomerase 4 subunit A
    Species: Streptococcus pneumoniae [TaxId:1313]
    Gene: parC, SP_0855
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3foeb_
  • Chain 'C':
    Compound: DNA topoisomerase 4 subunit B
    Species: Streptococcus pneumoniae [TaxId:1313]
    Gene: parE, SP_0852
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3foec_
  • Chain 'D':
    Compound: DNA topoisomerase 4 subunit B
    Species: Streptococcus pneumoniae [TaxId:1313]
    Gene: parE, SP_0852
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3foed_
  • Chain 'E':
    Compound: DNA (5'-d(p*ap*cp*cp*ap*ap*gp*gp*tp*cp*ap*tp*gp*ap*ap*t)-3')
  • Chain 'F':
    Compound: DNA (5'-d(p*ap*gp*tp*cp*ap*tp*tp*cp*ap*tp*gp*ap*cp*cp*tp*tp*gp*gp*t)-3')
  • Chain 'G':
    Compound: DNA (5'-d(p*cp*tp*gp*tp*tp*tp*tp*ap*cp*gp*tp*gp*cp*ap*t)-3')
  • Chain 'H':
    Compound: DNA (5'-d(p*gp*ap*cp*tp*ap*tp*gp*cp*ap*cp*gp*tp*ap*ap*ap*ap*cp*ap*g)-3')
  • Heterogens: NFX

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3foeA (A:)
msniqnmsledimgerfgryskyiiqdralpdirdglkpvqrrilysmnkdsntfdksyr
ksaksvgnimgnfhphgdssiydamvrmsqnwknreilvemhgnngsmdgdppaamryte
arlseiagyllqdiekktvpfawnfddtekeptvlpaafpnllvngstgisagyatdipp
hnlaevidaavymidhptakidklmeflpgpdfptgaiiqgrdeikkayetgkgrvvvrs
kteieklkggkeqiviteipyeinkanlvkkiddvrvnnkvagiaevrdesdrdglriai
elkkdantelvlnylfkytdlqinynfnmvaidnftprqvgivpilssyiahrrevilar
srfdkekaekrlhiveglirvisildevialirasenkadakenlkvsydfteeqaeaiv
tlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkkelrevkkkfatprls
sledtakalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3foeA (A:)
qnmsledimgerfgryskyiiqdralpdirdglkpvqrrilysmnkdsndksyrksaksv
gnimgnfhphgdssiydamvrmsqnwknreilvemhgnngsmdgdppaamrytearlsei
agyllqdiekktvpfawnfddtekeptvlpaafpnllvntdipphnlaevidaavymidh
ptkidklmeflpgpdfptiiqgrdeikkayetggrvvvrskteieklkggkeqivitein
kanlvkkiddvrvnnkvieltelvlnylfkytdlqinynfnmvaidnftprqvgivpils
syiahrrevilarsrfdkekaekrlhiveglirvisildevialirasenkadakenlkv
sydfteeqaeaivtlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkkel
revkkkfatprl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3foeB (B:)
msniqnmsledimgerfgryskyiiqdralpdirdglkpvqrrilysmnkdsntfdksyr
ksaksvgnimgnfhphgdssiydamvrmsqnwknreilvemhgnngsmdgdppaamryte
arlseiagyllqdiekktvpfawnfddtekeptvlpaafpnllvngstgisagyatdipp
hnlaevidaavymidhptakidklmeflpgpdfptgaiiqgrdeikkayetgkgrvvvrs
kteieklkggkeqiviteipyeinkanlvkkiddvrvnnkvagiaevrdesdrdglriai
elkkdantelvlnylfkytdlqinynfnmvaidnftprqvgivpilssyiahrrevilar
srfdkekaekrlhiveglirvisildevialirasenkadakenlkvsydfteeqaeaiv
tlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkkelrevkkkfatprls
sledtakalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3foeB (B:)
qnmsledimgerfgryskyiiqdralpdirdglkpvqrrilysmnkdsntfdksyrksak
svgnimgnfhphgdssiydamvrmsqnwknreilvemhgnngsmdgdppaamrytearls
eiagyllqdiekktvpfawnfddtekeptvlpaafpnllvntdipphnlaevidaavymi
dhptakidklmeflpgpdfptiiqgrdeikkayetgkgrvvvrseieklkggkeqivite
inkanlvkkiddvrvnnkvielntelvlnylfkytdlqinfnmvaidnftprqvgivpil
ssyiahrrevilarsrfdkekaekrlhiveglirvisildevialirasenkadakenlk
vsydfteeqaeaivtlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkke
lrevkkkfatprl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3foeC (C:)
mghhhhhhhhhhssghiddddkhmknkkdkgllsgkltpaqsknpaknelylvegdsagg
sakqgrdrkfqailplrgkvintakakmadilkneeintmiytigagvgadfsiedanyd
kiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmskgkgkkeevayaw
tdgeleelrkqfgkgatlqrykglgemnadqlwettmnpetrtlirvtiedlaraerrvn
vlmgdkveprrkwiednvkftleeatvf

    Sequence, based on observed residues (ATOM records): (download) 
    >3foeC (C:)
tpaqsknpaknelylvegdsaggsakqgrdrkfilplrvintakakmadilkneeintmi
ytigagvgkiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmskgkgk
keayawtdgeleelkgatlqrykglgemdqlwettmnpetrtlirvtiedlaraerrvnv
lmgdkveprrkwiedn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3foeD (D:)
mghhhhhhhhhhssghiddddkhmknkkdkgllsgkltpaqsknpaknelylvegdsagg
sakqgrdrkfqailplrgkvintakakmadilkneeintmiytigagvgadfsiedanyd
kiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmskgkgkkeevayaw
tdgeleelrkqfgkgatlqrykglgemnadqlwettmnpetrtlirvtiedlaraerrvn
vlmgdkveprrkwiednvkftleeatvf

    Sequence, based on observed residues (ATOM records): (download) 
    >3foeD (D:)
tpaqsknpaknelylvegdsaggsakqgrdrkfilplrvintakakmadilkneeintmi
ytigagvgkiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmskgkgk
keevayawtdgeleelkgatlqrykglgemdqlwettmnpetrtlirvtiedlaraerrv
nvlmgdkveprrkwiedn

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.