PDB entry 3fli

View 3fli on RCSB PDB site
Description: Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)
Class: transcription
Keywords: FXR, BAR, NR1H4, BILE ACID RECEPTOR, NUCLEAR RECEPTOR, LIGAND-BINDING DOMAIN, ALPHA-HELICAL SANDWICH, TRANSCRIPTIONAL REGULATOR, DNA-BINDING, METAL-BINDING, NUCLEUS, REPRESSOR, TRANSCRIPTION, Activator, Alternative splicing, Receptor, Transcription regulation, Zinc, Zinc-finger
Deposited on 2008-12-18, released 2009-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-12-22, with a file datestamp of 2009-12-18.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.193
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bile acid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: BAR, FXR, HRR1, NR1H4, RIP14
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3flia_
  • Heterogens: 33Y, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fliA (A:)
gseltpdqqtllhfimdsynkqrmpqeitnkilkeefsaeenfliltematnhvqvlvef
tkklpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdlleerirnsgisdey
itpmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklcki
hqpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdvq

    Sequence, based on observed residues (ATOM records): (download) 
    >3fliA (A:)
eltpdqqtllhfimdsynkqrmpqeitnkilkeefsaeenfliltematnhvqvlveftk
klpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdlleerirnsgisdeyit
pmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckihq
penpqhfacllgrltelrtfnhhhaemlmsftpllceiwdv