PDB entry 3fi4

View 3fi4 on RCSB PDB site
Description: P38 kinase crystal structure in complex with RO4499
Class: signaling protein, transferase
Keywords: P38; MAP KINASE; SERINE/THREONINE KINASE, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase, SIGNALING PROTEIN
Deposited on 2008-12-10, released 2009-12-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-12-22, with a file datestamp of 2009-12-18.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.212
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16539
      • engineered (68)
    Domains in SCOPe 2.06: d3fi4a_
  • Heterogens: FI4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3fi4A (A:)
    mrgshhhhhhgsmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktgl
    rvavkklskpfqsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthl
    mgadlnnivkcqkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkild
    fglarhtddemtgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdh
    idqlklilrlvgtpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekm
    lvldsdkritaaqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisf
    vpppldqeemes
    

    Sequence, based on observed residues (ATOM records): (download)
    >3fi4A (A:)
    erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklskpfqsii
    hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnniddhvqfl
    iyqilrglkyihsadiihrdlkpsnlavnedcelkildfgltddemtgyvatrwyrapei
    mlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisse
    sarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhd
    pddepvadpydqsfesrdllidewksltydevisfvppp