PDB entry 3fi2

View 3fi2 on RCSB PDB site
Description: Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451
Class: Transferase
Keywords: JNK3, protein-inhibitor complex, Alternative splicing, ATP-binding, Chromosomal rearrangement, Cytoplasm, Epilepsy, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2008-12-10, released 2009-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-06-23, with a file datestamp of 2009-06-19.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: 0.189
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: JNK3, JNK3A, MAPK10, PRKM10
    Database cross-references and differences (RAF-indexed):
    • Uniprot P53779
      • see remark 999 (325-330)
    Domains in SCOPe 2.08: d3fi2a_
  • Heterogens: JK1, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fi2A (A:)
mskskvdnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrp
fqnqthakrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviq
meldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsf
mmtpyvvtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieq
lgtpcpefmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllsk
mlvidpakrisvddalqhpyinvwyxxxxxxderehtieewkeliykevmnse

    Sequence, based on observed residues (ATOM records): (download) 
    >3fi2A (A:)
dnqfysvevgdstftvlkryqnlkpigivcaaydavldrnvaikklsrpfqnqthakray
relvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyl
lyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglarvtryyrapevilgmgyk
envdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyvenr
pkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyinv
wyxxxxxxderehtieewkeliykevmn