PDB entry 3fgm

View 3fgm on RCSB PDB site
Description: Crystal structure of L44F/C83T/C117V/F132W mutant of Human acidic fibroblast growth factor
Class: hormone
Keywords: beta-trefoil, Acetylation, Angiogenesis, Developmental protein, Differentiation, Growth factor, Heparin-binding, Mitogen, Polymorphism, HORMONE
Deposited on 2008-12-06, released 2009-10-06
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-10-13, with a file datestamp of 2009-10-09.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.206
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heparin-binding growth factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF1, FGFA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NVQ3
      • engineered (49)
      • engineered (88)
      • engineered (122)
      • engineered (137)
    Domains in SCOPe 2.04: d3fgma_
  • Chain 'B':
    Compound: heparin-binding growth factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF1, FGFA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NVQ3
      • engineered (49)
      • engineered (88)
      • engineered (122)
      • engineered (137)
    Domains in SCOPe 2.04: d3fgmb_
  • Heterogens: SO4, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3fgmA (A:)
    hhhhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqfqlsaesvgev
    yikstetgqylamdtdgllygsqtpneetlflerleenhyntyiskkhaeknwfvglkkn
    gsvkrgprthygqkailwlplpvssd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3fgmA (A:)
    hhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqfqlsaesvgevyi
    kstetgqylamdtdgllygsqtpneetlflerleenhyntyiskkhaeknwfvglkkngs
    vkrgprthygqkailwlplpv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3fgmB (B:)
    hhhhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqfqlsaesvgev
    yikstetgqylamdtdgllygsqtpneetlflerleenhyntyiskkhaeknwfvglkkn
    gsvkrgprthygqkailwlplpvssd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3fgmB (B:)
    hhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqfqlsaesvgevyi
    kstetgqylamdtdgllygsqtpneetlflerleenhyntyiskkhaeknwfvglkkngs
    vkrgprthygqkailwlplpv