PDB entry 3fga

View 3fga on RCSB PDB site
Description: Structural Basis of PP2A and Sgo interaction
Class: HYDROLASE/hydrolase inhibitor
Keywords: PP2A, shugoshin, Nucleus, Phosphoprotein, Hydrolase, Iron, Manganese, Metal-binding, Methylation, Protein phosphatase, Cell cycle, Cell division, Centromere, Chromosome partition, Mitosis, HYDROLASE-hydrolase inhibitor complex
Deposited on 2008-12-05, released 2009-09-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Species: Mus musculus [TaxId:10090]
    Gene: PP2A, Ppp2r1a, subunit A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3fgaa_
  • Chain 'B':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: KIAA0044, PP2A, PPP2R5C, subunit B'
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PP2A, PPP2CA, subunit c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P67775 (Start-308)
      • engineered (87)
    Domains in SCOPe 2.08: d3fgac_
  • Chain 'D':
    Compound: Shugoshin-like 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SGO1, SGOL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5FBB7 (1-46)
      • insertion (0)
  • Chain 'E':
    Compound: microcystin-lr
    Species: MICROCYSTIS AERUGINOSA, synthetic [TaxId:1126]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Heterogens: MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fgaA (A:)
aaadgddslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiyd
edevllalaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehsp
sdleahfvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmv
rraaasklgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedle
alvmptlrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraa
ashkvkefcenlsadcrenvimtqilpcikelvsdanqhvksalasvimglspilgkdnt
iehllplflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrl
aiieympllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahat
iipkvlamsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnva
kslqkigpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

    Sequence, based on observed residues (ATOM records): (download) 
    >3fgaA (A:)
ddslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevl
lalaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdlea
hfvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaa
sklgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmp
tlrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkv
kefcenlsadcrenvimtqilpcikelvsdanqhvksalasvimglspilgkdntiehll
plflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiiey
mpllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkv
lamsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqk
igpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3fgaC (C:)
mdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhg
qfhdlmelfriggkspdtnylfmgdyvnrgyysvetvtllvalkvryreritilrgnhes
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhi
raldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsra
hqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgephv
trrtpdyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >3fgaC (C:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvnrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrtrrtpd
yfl

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.