PDB entry 3fe1

View 3fe1 on RCSB PDB site
Description: Crystal structure of the human 70kDa heat shock protein 6 (Hsp70B') ATPase domain in complex with ADP and inorganic phosphate
Class: chaperone
Keywords: mixed beta-sheet, ATP-binding, Nucleotide-binding, Polymorphism, Stress response, CHAPERONE, Structural Genomics, Structural Genomics Consortium, SGC
Deposited on 2008-11-27, released 2008-12-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-02-02, with a file datestamp of 2010-01-29.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.201
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock 70 kDa protein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: HSPA6, HSP70B'
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17066 (23-402)
      • expression tag (22)
    Domains in SCOPe 2.08: d3fe1a1, d3fe1a2, d3fe1a3
  • Chain 'B':
    Compound: Heat shock 70 kDa protein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: HSPA6, HSP70B'
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17066 (23-402)
      • expression tag (16-22)
    Domains in SCOPe 2.08: d3fe1b1, d3fe1b2, d3fe1b3
  • Chain 'C':
    Compound: Heat shock 70 kDa protein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: HSPA6, HSP70B'
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3fe1c1, d3fe1c2
  • Heterogens: ADP, PO4, MG, CL, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fe1A (A:)
mhhhhhhssgvdlgtenlyfqsmelavgidlgttyscvgvfqqgrveilandqgnrttps
yvaftdterlvgdaaksqaalnphntvfdakrligrkfadttvqsdmkhwpfrvvseggk
pkvrvcyrgedktfypeeissmvlskmketaeaylgqpvkhavitvpayfndsqrqatkd
agaiaglnvlriineptaaaiaygldrrgagernvlifdlgggtfdvsvlsidagvfevk
atagdthlggedfdnrlvnhfmeefrrkhgkdlsgnkralrrlrtacerakrtlssstqa
tleidslfegvdfytsitrarfeelcsdlfrstlepvekalrdakldkaqihdvvlvggs
tripkvqkllqdffngkelnksinpdeavaygaavqaavlmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >3fe1A (A:)
melavgidlgttyscvgvfqqgrveilandqgnrttpsyvaftdterlvgdaaksqaaln
phntvfdakrligrkfadttvqsdmkhwpfrvvseggkpkvrvcyrgedktfypeeissm
vlskmketaeaylgqpvkhavitvpayfndsqrqatkdagaiaglnvlriineptaaaia
ygldrrgagernvlifdlgggtfdvsvlsidagvfevkatagdthlggedfdnrlvnhfm
eefrrkhgkdlsgnkralrrlrtacerakrtlssstqatleidslfegvdfytsitrarf
eelcsdlfrstlepvekalrdakldkaqihdvvlvggstripkvqkllqdffngkelnks
inpdeavaygaavqaavlmgd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3fe1B (B:)
mhhhhhhssgvdlgtenlyfqsmelavgidlgttyscvgvfqqgrveilandqgnrttps
yvaftdterlvgdaaksqaalnphntvfdakrligrkfadttvqsdmkhwpfrvvseggk
pkvrvcyrgedktfypeeissmvlskmketaeaylgqpvkhavitvpayfndsqrqatkd
agaiaglnvlriineptaaaiaygldrrgagernvlifdlgggtfdvsvlsidagvfevk
atagdthlggedfdnrlvnhfmeefrrkhgkdlsgnkralrrlrtacerakrtlssstqa
tleidslfegvdfytsitrarfeelcsdlfrstlepvekalrdakldkaqihdvvlvggs
tripkvqkllqdffngkelnksinpdeavaygaavqaavlmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >3fe1B (B:)
nlyfqsmelavgidlgttyscvgvfqqgrveilandqgnrttpsyvaftdterlvgdaak
sqaalnphntvfdakrligrkfadttvqsdmkhwpfrvvseggkpkvrvcyrgedktfyp
eeissmvlskmketaeaylgqpvkhavitvpayfndsqrqatkdagaiaglnvlriinep
taaaiaygldrrgagernvlifdlgggtfdvsvlsidagvfevkatagdthlggedfdnr
lvnhfmeefrrkhgkdlsgnkralrrlrtacerakrtlssstqatleidslfegvdfyts
itrarfeelcsdlfrstlepvekalrdakldkaqihdvvlvggstripkvqkllqdffng
kelnksinpdeavaygaavqaavlmgd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3fe1C (C:)
mhhhhhhssgvdlgtenlyfqsmelavgidlgttyscvgvfqqgrveilandqgnrttps
yvaftdterlvgdaaksqaalnphntvfdakrligrkfadttvqsdmkhwpfrvvseggk
pkvrvcyrgedktfypeeissmvlskmketaeaylgqpvkhavitvpayfndsqrqatkd
agaiaglnvlriineptaaaiaygldrrgagernvlifdlgggtfdvsvlsidagvfevk
atagdthlggedfdnrlvnhfmeefrrkhgkdlsgnkralrrlrtacerakrtlssstqa
tleidslfegvdfytsitrarfeelcsdlfrstlepvekalrdakldkaqihdvvlvggs
tripkvqkllqdffngkelnksinpdeavaygaavqaavlmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >3fe1C (C:)
elavgidlgttyscvgvfqqgrveilandqgnrttpsyvaftdterlvgdaaksqaalnp
hntvfdakrligrkfadttvqsdmkhwpfrvvseggkpkvrvcyrgedktfypeeissmv
lskmketaeaylgqpvkhavitvpayfndsqrqatkdagaiaglnvlriineptaaaiay
gldrrgagernvlifdlgggtfdvsvlsidagvfevkatagdthlggedfdnrlvnhfme
efrrkhgkdlsgnkralrrlrtacerakrtlssstqatleidslfegvdfytsitrarfe
elcsdlfrstlepvekalrdakldkaqihdvvlvggstripkvqkllqdffngkelnksi
npdeavaygaavqaavlmg