PDB entry 3fdn
View 3fdn on RCSB PDB site
Description: Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity
Class: Transferase
Keywords: Aurora kinase inhibitors, Virtual screening, X-ray co-crystal analysis, Structure-based drug design (SBDD), H-bonding., ATP-binding, Cell cycle, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase
Deposited on
2008-11-26, released
2009-09-15
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-09-15, with a file datestamp of
2009-09-11.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.231
AEROSPACI score: 0.42
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: serine/threonine-protein kinase 6
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3fdna_ - Heterogens: MMH, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3fdnA (A:)
skkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrrev
eiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelan
alsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrtdlcgtldylppemie
grmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisr
llkhnpsqrpmlrevlehpwitansskpsncqnkesask
Sequence, based on observed residues (ATOM records): (download)
>3fdnA (A:)
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhacgtldylppemiegrmhdekvdlw
slgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpm
lrevlehpwitansskpsncq