PDB entry 3fde

View 3fde on RCSB PDB site
Description: Mouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1) at 1.4 A resolution
Class: ligase
Keywords: SRA domain, base flipping, DNA CpG methylation, Cell cycle, Developmental protein, DNA damage, DNA repair, DNA-binding, Ligase, Metal-binding, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
Deposited on 2008-11-25, released 2009-01-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-03-24, with a file datestamp of 2009-03-20.
Experiment type: XRAY
Resolution: 1.41 Å
R-factor: 0.151
AEROSPACI score: 0.7 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase UHRF1
    Species: Mus musculus [TaxId:10090]
    Gene: Np95, Uhrf1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8VDF2 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d3fdea1, d3fdea2
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase UHRF1
    Species: Mus musculus [TaxId:10090]
    Gene: Np95, Uhrf1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8VDF2 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d3fdeb1, d3fdeb2
  • Chain 'C':
    Compound: 5'-d(*cp*cp*ap*tp*gp*(5cm)p*gp*cp*tp*gp*ap*c)-3'
    Species: synthetic, synthetic
  • Chain 'D':
    Compound: 5'-d(*cp*cp*ap*tp*gp*(5cm)p*gp*cp*tp*gp*ap*c)-3'
    Species: synthetic, synthetic
  • Chain 'E':
    Compound: 5'-d(*gp*tp*cp*ap*gp*cp*gp*cp*ap*tp*gp*g)-3'
    Species: synthetic, synthetic
  • Chain 'F':
    Compound: 5'-d(*gp*tp*cp*ap*gp*cp*gp*cp*ap*tp*gp*g)-3'
    Species: synthetic, synthetic
  • Heterogens: EDO, NA, UNL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fdeA (A:)
hmpanhfgpipgvpvgtmwrfrvqvsesgvhrphvagihgrsndgayslvlaggyeddvd
ngnyftytgsggrdlsgnkrtagqssdqkltnnnralalnchspinekgaeaedwrqgkp
vrvvrnmkggkhskyapaegnrydgiykvvkywpergksgflvwryllrrddtepepwtr
egkdrtrqlgltmqypegylealankeksrkr

    Sequence, based on observed residues (ATOM records): (download) 
    >3fdeA (A:)
hmpanhfgpipgvpvgtmwrfrvqvsesgvhrphvagihgrsndgayslvlaggyeddvd
ngnyftytgsggrdlsgnkrtagqssdqkltnnnralalnchspinekgaeaedwrqgkp
vrvvrnmkggkhskyapaegnrydgiykvvkywpergksgflvwryllrrddtepepwtr
egkdrtrqlgltmqypegylealankeksr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3fdeB (B:)
hmpanhfgpipgvpvgtmwrfrvqvsesgvhrphvagihgrsndgayslvlaggyeddvd
ngnyftytgsggrdlsgnkrtagqssdqkltnnnralalnchspinekgaeaedwrqgkp
vrvvrnmkggkhskyapaegnrydgiykvvkywpergksgflvwryllrrddtepepwtr
egkdrtrqlgltmqypegylealankeksrkr

    Sequence, based on observed residues (ATOM records): (download) 
    >3fdeB (B:)
hmpanhfgpipgvpvgtmwrfrvqvsesgvhrphvagihgrsndgayslvlaggyeddvd
ngnyftytgsggrdlsgnkrtagqssdqkltnnnralalnchspinekgaeaedwrqgkp
vrvvrnmkggkhskyapaegnrydgiykvvkywpergksgflvwryllrrddtepepwtr
egkdrtrqlgltmqypegylealank

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.