PDB entry 3fal

View 3fal on RCSB PDB site
Description: humanRXR alpha & mouse LXR alpha complexed with Retenoic acid and GSK2186
Class: signaling protein
Keywords: Nuclear hormone receptor nonsteroidal LXR agonist choloestorol metabolism, DNA-binding, Host-virus interaction, Metal-binding, Nucleus, Polymorphism, Receptor, Transcription, Transcription regulation, Ubl conjugation, Zinc, Zinc-finger, SIGNALING PROTEIN
Deposited on 2008-11-17, released 2009-04-14
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-04-14, with a file datestamp of 2009-04-10.
Experiment type: XRAY
Resolution: 2.36 Å
R-factor: 0.222
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoic acid receptor RXR-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: RXRA, NR2B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3fala_
  • Chain 'B':
    Compound: Oxysterols receptor LXR-alpha
    Species: Mus musculus [TaxId:10090]
    Gene: Nr1h3, Lxra
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Z0Y9
      • see remark 999 (219)
  • Chain 'C':
    Compound: Retinoic acid receptor RXR-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: RXRA, NR2B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3falc_
  • Chain 'D':
    Compound: Oxysterols receptor LXR-alpha
    Species: Mus musculus [TaxId:10090]
    Gene: Nr1h3, Lxra
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Z0Y9
      • see remark 999 (219)
  • Heterogens: REA, LO2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3falA (A:)
mkkgsanedmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlv
ewakriphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsa
gvgaifdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasl
eayckhkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphq
mt

    Sequence, based on observed residues (ATOM records): (download) 
    >3falA (A:)
nedmpverileaelavdpvtnicqaadkqlftlvewakriphfselplddqvillragwn
elliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmqmdkte
lgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllrlpalr
siglkcltflmemlea

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3falC (C:)
mkkgsanedmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlv
ewakriphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsa
gvgaifdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasl
eayckhkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphq
mt

    Sequence, based on observed residues (ATOM records): (download) 
    >3falC (C:)
sanedmpverileaelavdpvtnicqaadkqlftlvewakriphfselplddqvillrag
wnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmqmdk
telgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllrlpa
lrsiglkcltflmemlea

  • Chain 'D':
    No sequence available.