PDB entry 3f9x

View 3f9x on RCSB PDB site
Description: structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me2 / adohcy
Deposited on 2008-11-14, released 2008-11-25
The last revision was dated 2021-10-20, with a file datestamp of 2021-10-15.
Experiment type: XRAY
Resolution: 1.25 Å
R-factor: N/A
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone-lysine N-methyltransferase SETD8
    Species: Homo sapiens [TaxId:9606]
    Gene: SETD8, KMT5A, PRSET7, SET07, SET8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NQR1 (4-165)
      • expression tag (0-3)
      • engineered mutation (147)
  • Chain 'B':
    Compound: Histone-lysine N-methyltransferase SETD8
    Species: Homo sapiens [TaxId:9606]
    Gene: SETD8, KMT5A, PRSET7, SET07, SET8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NQR1 (4-165)
      • expression tag (0-3)
      • engineered mutation (147)
  • Chain 'C':
    Compound: Histone-lysine N-methyltransferase SETD8
    Species: Homo sapiens [TaxId:9606]
    Gene: SETD8, KMT5A, PRSET7, SET07, SET8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NQR1 (4-165)
      • expression tag (0-3)
      • engineered mutation (147)
  • Chain 'D':
    Compound: Histone-lysine N-methyltransferase SETD8
    Species: Homo sapiens [TaxId:9606]
    Gene: SETD8, KMT5A, PRSET7, SET07, SET8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NQR1 (4-165)
      • expression tag (0-3)
      • engineered mutation (147)
  • Chain 'E':
    Compound: histone h4
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: histone h4
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: histone h4
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: histone h4
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SAH, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3f9xA (A:)
gamgsrkskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyh
gdlieitdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncq
tklhdidgvphliliasrdiaageellfdygdrskasieahpwlkh

    Sequence, based on observed residues (ATOM records):
    >3f9xA (A:)
kskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyhgdliei
tdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncqtklhdi
dgvphliliasrdiaageellfdygdrskasieahpwlkh

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3f9xB (B:)
gamgsrkskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyh
gdlieitdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncq
tklhdidgvphliliasrdiaageellfdygdrskasieahpwlkh

    Sequence, based on observed residues (ATOM records):
    >3f9xB (B:)
kskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyhgdliei
tdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncqtklhdi
dgvphliliasrdiaageellfdygdrskasieahpwlkh

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3f9xC (C:)
gamgsrkskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyh
gdlieitdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncq
tklhdidgvphliliasrdiaageellfdygdrskasieahpwlkh

    Sequence, based on observed residues (ATOM records):
    >3f9xC (C:)
kskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyhgdliei
tdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncqtklhdi
dgvphliliasrdiaageellfdygdrskasieahpwlkh

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3f9xD (D:)
gamgsrkskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyh
gdlieitdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncq
tklhdidgvphliliasrdiaageellfdygdrskasieahpwlkh

    Sequence, based on observed residues (ATOM records):
    >3f9xD (D:)
rkskaelqseerkrideliesgkeegmkidlidgkgrgviatkqfsrgdfvveyhgdlie
itdakkrealyaqdpstgcymyyfqylsktycvdatretnrlgrlinhskcgncqtklhd
idgvphliliasrdiaageellfdygdrskasieahpwlkh

  • Chain 'E':
    Sequence, based on SEQRES records:
    >3f9xE (E:)
akrhrkvlrd

    Sequence, based on observed residues (ATOM records):
    >3f9xE (E:)
krhrkvlrd

  • Chain 'F':
    Sequence, based on SEQRES records:
    >3f9xF (F:)
akrhrkvlrd

    Sequence, based on observed residues (ATOM records):
    >3f9xF (F:)
krhrkvlr

  • Chain 'G':
    Sequence, based on SEQRES records:
    >3f9xG (G:)
akrhrkvlrd

    Sequence, based on observed residues (ATOM records):
    >3f9xG (G:)
krhrkvlrd

  • Chain 'H':
    Sequence, based on SEQRES records:
    >3f9xH (H:)
akrhrkvlrd

    Sequence, based on observed residues (ATOM records):
    >3f9xH (H:)
krhrkvlr